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Data available in the literature demonstrate that i circulating estrogens are involved in gonadotropin suppression both at pituitary 146 and hypothalamic level 128, 149, and ii estrogen effects on hypothalamus are independent from central aromatization, but requires adequate amounts of circulating estrogens in normal healthy men 146, in men with IHH 149, 150, and in men with aromatase deficiency 128 ivermectin for goats 003, two sided Student s t test following logarithmic transformation
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